Prof. Lynae Brayboy, M.D.

Expertise

Dr. Brayboy is a Reproductive Scientist Development Alumna supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development K12. Her K12 research examined how multidrug transporters safeguard the normal mammalian ovary from toxicants and chemotherapeutics. Her new preliminary data show there a link between oocyte mitochondrial physiology and multidrug resistance transporters. Dr. Brayboy is now supported by the Global Consortium for Reproductive Longevity and Equality Junior Faculty Fellowship Program.

Dr. Brayboy received her undergraduate degree in Biology from Florida A & M University in Tallahassee, Florida. She graduated with her MD from Temple University School of Medicine in Philadelphia, Pennsylvania. She was a resident in Obstetrics and Gynecology at Abington Memorial Hospital in Abington, Pennsylvania. She finished her fellowship in Reproductive Endocrinology and Infertility in 2014. Dr. Brayboy is also a graduate of the Frontiers in Reproduction Course at Woods Hole, Massachusetts.

Publications

1. Wilthsire A, Ghidei L, Brayboy LM. Infertility and Assisted Reproductive Technology Outcomes in Afro-Caribbean Women J Assist Reprod Genet 2020 May 27.doi: 10.1007/s10815-020-01826-2. Online ahead of print.
2. Zijing Zhang, Florencia Schlamp, Lu Huang, Haley Clark, Brayboy LM Inflammaging is associated with shifted macrophage ontogeny and polarization in the mouse ovary. Reproduction. 2020 Mar;159(3):325-337. doi: 10.1530/REP-19-0330. PMID: 31940276
3. Wiltshire A, Brayboy LM, Phillips K, Matthews R, Yan F, McCarthy-Keith D. Infertility knowledge and treatment beliefs among African American women in an urban community. Contracept Reprod Med. 2019;4:16. doi: 10.1186/s40834-019-0097-x. eCollection 2019. PubMed PMID: 31572616; PubMed Central PMCID: PMC6757383
4. Haley Clark, Laura O. Knapik, Zijing Zhang, Xiaotian Wu, Mandar T. Naik, Gary M. Wessel, Brayboy LM Dysfunctional MDR-1 disrupts mitochondrial homeostasis in the oocyte and ovary Sci Rep. 2019 Jul 3;9(1):9616. doi: 10.1038/s41598-019-46025-x. PubMed PMID: 31270386; PubMed Central PMCID: PMC6610133.
5. Brayboy LM, Knapik LO, Long S, Westrick M, Wessel GM. Ovarian hormones modulate multidrug resistance transporters in the ovary. Contraception and Reprod Med. (2018) 3:26. PMID: 30460040
6. Brayboy LM, Clark H, Knapik LO, Schnirman RE, Wessel GM. Nitrogen mustard exposure perturbs oocyte mitochondrial physiology and alters reproductive outcomes. Reprod Toxicol. 2018 Oct 9;82:80-87. PMID 30308227.
7. Brayboy LM, McCoy K, Thamotharan S, Zhu E, Gil G, Houck C. The use of technology in the sexual health education especially among minority adolescent girls in the United States. Curr Opin Obstet Gynecol. 2018 Oct;30(5):305-309. PMID 30153129.
8. Brayboy LM, Oulhen N, Long S, Voigt N, Raker C, Wessel GM. Multidrug resistance transporter-1 and breast cancer resistance protein protect against ovarian toxicity and are essential in ovarian physiology. Reprod Toxicol. 2017 Apr;69:121-131. Epub 2017 Feb 12. PMID 28216407.
9. Brayboy LM, Sepolen A, Mezoian T, Mills BL, Wheeler C, Clark M. Girl Talk: A smartphone application to teach girls sexual education. J of Pediatr and Adolesc Gynecol. 2017;30(1):23-28. NIHMSID: NIHMS901394.
10. Brayboy LM, Wessel G. The double-edged sword of the mammalian oocyte – advantages, drawbacks and approaches for basic and clinical analysis. Mol Hum Reprod. 2015 Nov 19. PMID 26590170.
11. Angione S, Oulhen N, Brayboy LM, Tripathi A, Wessel GM. Simple perfusion apparatus (SPA) for manipulation, tracking, and study of oocytes and embryos. Fertil and Steril. 2015 Jan;103(1):281-290.e5. PMID 25450296
12. Brayboy LM, Oulhen N, Witmyer J, Robins J, Carson S, Wessel GM. Multidrug resistant transport activity protects oocytes from chemotherapeutic agents and changes during oocyte maturation. Fertil and Steril. 100(5):1428-35. 2013 Aug 13. PMID 23953328
13. Wessel GM, Brayboy LM, Fresques T, Gustafson EA, Oulhen N, Ramos I, Reich A, Swartz SZ, Yajima M, Zazueta V. The biology of the germ line in echinoderms. Mol Reprod Dev. 2013 Jul 30. PMID 23900765
14. Michalakis KG, Mesen TB, Brayboy LM, Yu B, Richter KS, Segars, JH. Subclinical elevations of thyroid-stimulating hormone and assisted reproductive technology outcomes. Fertil and Steril. 2011 Jun 30;95(8):2634-7. doi: 10.1016/j.fertnstert.2011.02.056. PMID:21457968

Invited presentations

1. “Fertility and Egg Quality as a Marker of Overall Health” Indiana University Department of Obstetrics and Gynecology Grand Rounds 5.20.2020
2. Rhode Island Women's Health Summit Sex and Gender, Medical Research, and our Community: Redefining Women’s Health in Rhode Island March 13-14
3. “Dysfunctional MDR-1 disrupts mitochondrial homeostasis in the oocyte and ovary” IRI Life Sciences, Humboldt-Universität zu Berlin, Berlin, Germany December 4, 2019.
4. “Dysfunctional MDR-1 disrupts mitochondrial homeostasis in the oocyte and ovary” Spain IVI RMA December 2, 2019
5. “Reproductive and Pregnancy Outcomes of Patients Treated with Alkylating Chemotherapy” Society for Reproductive Investigation Paris, France March 14, 2019
6. “P-glycoprotein loss in the ovary is associated with increased vulnerability to toxicants, oxidative stress, metabolic dysfunction,” Reproductive Scientist Development Program (RSDP) Annual Retreat, Philadelphia PA, September 8, 2018.
7. “MDR-1 loss in the ovary is associated with increased vulnerability to toxicants, oxidative stress, and metabolic dysfunction,” 21st Annual Frontiers in Reproduction Symposium, Woods Hole MA, June 8, 2018.
8. “Girl Talk: A Smartphone Application to Teach Sexual Health Education to Adolescent Girls,” NASPAG Annual Meeting, West Palm Beach FL, April 12, 2018.
9. “P-glycoprotein loss in the ovary is associated with increased vulnerability to toxicants, oxidative stress, and metabolic dysfunction,” University of Massachusetts, Amherst MA, February 12, 2018.
10. “Designing Research to Inform Clinical Practice,” The Promise of Genome Editing Tools to Advance Environmental Health Research, National Academy of Sciences, Engineering, and Medicine workshop, Washington DC, January 11, 2018.
11. Women’s Health and Reproductive Topics, Lectures (33), Lecturio e-learning platform, Leipzig, Germany, April 2017.
12. “Careers in Research and Medicine,” Minority Association of Premed Students, Brown University, Providence RI, March 24, 2016.
13. “Molecular variations between the young and aged oocyte” American Society of Reproductive Immunology, Baltimore MD November 2016

Links

Tracing the Origins of Female Infertility

a portrait of Lynae M. Brayboy by Nicola von Lutterotti

www.wiko-berlin.de/en/wikotheque/koepfe-und-ideen/issue/15/den-ursachen-weiblicher-infertilitaet-auf-der-spur

Networking

Translational Genomics
Campus Charité Mitte (CCM)

Gynecology, Perinatal, Pediatric a& Adolescent Medicine with Perinatal Center & Human Genetics (CC 17)

Campus Charité Mitte
(CCM)